Every two weeks a new boss that has a very unique setting that you can work your roaster on in MARVEL Mystic Mayhem – this is Nightfall mode. Below we have working teams for you as well as some strategies that work well when dealing woth the bosses so you can constantly push out as many points as possible to get more rewards.
Also, please make sure to check out the best teams overall here also for the other modes in MARVEL Mystic Mayhem and also the tier list with builds linked for every hero here.
Best Nightfall Bosses (Ordered From Current to Previous)

Best Dragon Armor Teams
You literally have a dragon breathing down your neck here while you’re forced to clear the mob waves quickly and then deal damage to the dragon itself while also dealing with the summons before they will accumulate and become a problem – a good mix between AoE damage and some single-target damage to take down the boss is vital here
Best Dragon Armor Team
Yeah no surprise that the release of Captain America comes at the same time here and he is simply too strong in this mode to not shape the meta team here
Alternative Dragon Armor Team
This is for many people at this point a team you can run, espcailly Thor amkes it a lot easier to deal with the mobs
Alternative Dragon Armor Team
If that’s all you got, this team works as well and if you build the heroes well, including their artifacts, you can still get solid results here

Best Eye of Nightmare Teams
You have to destroy the respawning hands on order to ‘unlock’ the core. Once both hands are down, you can actually damage the boss. Important here is to time that since the hands will respawn! Destroy one hand to like 20% and then switch to ther other one and take it down. Then take down the first one. Otherwise the hands will re-spawn and re-spawn and it takes a lot longer to actually be able to target the boss!
Best Eye of Nightmare Team
I know, a hell of a team here and nothing easily accessible but the best one here, espcially when it comes to the higher difficulties. Amazing damage output and some healing from Doctor Strange since the chip damage on your heroes accumulates over time
Alternative Eye of Nightmare Team
For most players the easy go-to-team here to focus the hands down and then crack the boss itself
Conclusion
I hope this overview here helps you and if you have a secret team that you think should be menioned here, please post it in the comments and we will be more than happy to take a look at it.