Rotating bosses throughout the week challenge your MARVEL Mystic Mayhem roaster here since you want to beat the bigher levels for better artifacts to build the right ones (you might recall the important lessons about building only artifacts with the right stats, check out our hero build guides for reference) – at the same time each boss will challenge your team differently and only follwoing the recommended 3 heroes in the game will let you hit a wall rather sooner than later.
That’s why we have a full guide here with the teams that work best (mostly for those of you having some legendaries) and also alternatives that still should get you far enough to decently farm the bosses on a daily basis. Also, please check out here our full team hub for MARVEL Mystic Mayhem for all teams for all modes and the buids for all heroes.
Important! Important! Important! If you can’t build a team recommended here, use the best heroes you have. This is your shot. We only have teams here that have significant synergy to make sure that you do well with those team and do not list *any* possible team.

Lady Bullseye (Wipe Them Out)
Best Team for Lady Bullseye (Wipe Them Out)
I know loads of legendaries here but you will get there or if you invest money you are. Still, this is by far the most effective team against this boss to use if you can have it. Make sure to follow our recommendations for the hero builds!
F2P Alternative for Lady Bullseye (Wipe Them Out)
Emma Frost is really core here so you can’t substitute her but instead of Iron Man you can work with this team here that also deals quite well and efficently.
F2P Alternative for Lady Bullseye (Wipe Them Out)
Emma Frost is really core here so you can’t substitute her but instead of Iron Man you can work with this team here that also deals quite well and efficently.

Mister Negative (Do Or Die)
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Juggernaut (Arcane Avatar)
Best Team for Juggernaut (Arcane Avatar)
Special Damage is the can opener here
F2P Alternative for Juggernaut (Arcane Avatar)
Alternative Special Damage heroes here.
F2P Alternative for Juggernaut (Arcane Avatar)
If you need another hero to fill, Lady Bullseye works as well here although she will get the resistance on her damage since she doesn’t deal Special Damage. Still, she deals enough damage to make her worth the swap in

Thread (Brutal Onslaight)
Best Team for Thread (Brutal Onslaight)
Physical Damage is key here an no other heroes make much sense and since the number of heroes that do well with physical damage are rare, this is right now the best team
F2P Alternative for Thread (Brutal Onslaight)
Alternative version here and don’t be afraid to run two defenders here, both can deal enough damage to make them worth it compared to any other hero that doesn’t deal physical damage.

Doppelganger (Pick The Battle)
Best Team for Doppelganger (Pick The Battle)
You need to focus down each one here
F2P Alternative for Doppelganger (Pick The Battle)
With the non-legandries it’s easier if you use the prange and blue weakness to target your talents
Conclusion
Hope this overview helps you and if you have a team that works really well that you feel should be listed here, please drop a comment below and we will be more than happy to take it in and test it.