Best Sanguine Maria Builds in RAID Shadow Legends (PvE/PvP – with Artifacts, Stats & Masteries)

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Are you wondering how to build Sanguine Maria right in RAID Shadow Legends? Well, there’s so many builds out there and we didn’t just want to add another one jsut because, we wanted the core important artifacts and masteries here. The info that 95% of players need and not what Blessing potentially would work best when you have every hero maxed out in RAID Shadow Legends.

Important! Don’t miss our hero tier list that I just updated to see how Sanguine Maria performs among all heroes in the game and for the different game modes there are.

Sanguine MariaTier A+
Sanguine Maria
Tier List

Best Sanguine Maria Masteries + Artifacts

To wanted to make this all here as easy and accessible as possible, so we have clear use-cases for your hero and what Masteries and Artifacts to go for.

↙️ Please select what you want to use your Sanguine Maria for ↘️

PvEPvE
PvPPvP

Tap a gear slot to see its recommended sub stats

Great:MercilessandSavageSet
Alternative:LethalandCruelSet
Backup:PerceptionSet

How to use priority filters?

raid shadow legend filters


Tap a gear slot to see its recommended sub stats

Great:MercilessandSavageSet
Alternative:LethalandCruelSet
Backup:StoneskinSet

How to use priority filters?

raid shadow legend filters


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Relics and Gemstones

Big Relic Update! We have re-tested the relics with the latest added relics (Coalescence Group) early August 2026.

We continously test relics and also add newer relics to our builds to make usre they reflect what is currently available in the game and this is from our tests the idea setup in terms of relics:

Bane of Sintranos
Bane of Sintranos
Extra PunishmentExtra PunishmentTorpidityTorpidityPuppetmasterPuppetmasterUnerring FocusUnerring Focus
Chrysalid of Rebirth
Chrysalid of Rebirth
Maximum VelocityMaximum VelocityRevivals BoonRevivals BoonStrengthening WillStrengthening WillUndead BulwarkUndead Bulwark
Dreadbomb
Dreadbomb
Unrelenting PowerUnrelenting PowerCritical StrategyCritical StrategyPierce DefencesPierce DefencesBoss SlayerBoss Slayer
Chronocube
Chronocube
Maximum VelocityMaximum VelocitySkill AdeptSkill AdeptUnflinchingUnflinchingBoss SlayerBoss Slayer
Infernal Polytope
Infernal Polytope
Power ResetPower ResetPrecision RemovalPrecision RemovalDamage MitigationDamage MitigationDungeon DelverDungeon Delver
Lens of Intangibility
Lens of Intangibility
Critical StrategyCritical StrategyPierce DefencesPierce DefencesPuppetmasterPuppetmasterUnerring FocusUnerring Focus
Perched Shadow
Perched Shadow
Gathering MomentumGathering MomentumExpeditious ExplorationExpeditious Exploration
Volcardiac Heart
Volcardiac Heart
Damage MitigationDamage MitigationSteadfast PreparationSteadfast PreparationUnflinchingUnflinchingBoss SlayerBoss Slayer
The Collective
The Collective
Critical StrategyCritical StrategyEnhanced ShotEnhanced ShotBoss SlayerBoss Slayer
Gorecrescent
Gorecrescent
Piercing StrikePiercing StrikeBloodthirsty ProwessBloodthirsty Prowess

This is everything you need to know to build Sanguine Maria to the best performance in RAID Shadow Legends. If you’re looking for complete builds for other heroes, please find them all linked the the frequently updated tier list here.

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